There is some evidence that taking non-steroidal anti-inflammatory drugs (NSAIDS) may interfere with the chemical signals which allow release of the egg at ovulation time, producing a syndrome known as LUFS or luteinised unruptured follicle syndrome. This phenomenon was noticed in women taking either the standard class of NSAIDs or the new generation COX-2 inhibitors. Stopping the medication reversed the effect, and ovulation was no longer delayed. (British Journal of Rheumatology35(5:458-462)
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